Society for Pediatric Anesthesia
We make anesthesia for children safer

Encouraging research, education, and scientific progress in the field of pediatric anesthesia

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Anesthesia and Brain Development in Your Child

On Dec. 14, 2016 the U.S. Food and Drug Administration (FDA) issued a safety announcement regarding the potential effect of anesthetics on children younger than 3 years of age. Recent studies suggest that a single, relatively short exposure to general anesthetic and sedation drugs in infants or toddlers is unlikely to have negative effects on behavior or learning. However, further research is needed to fully characterize how early life anesthetic exposure affects children’s brain development. To better inform the public about this potential risk, we have taken points from the FDA’s communication and are sharing those with families to help them make educated decisions about the care of their young child.

Facts About General Anesthetic and Sedation Drugs
  • General anesthetic and sedation drugs are used to put infants and children into a deep sleep so they do not feel pain during surgery or procedures.
  • These drugs are usually injected into a vein or inhaled through a mask or breathing tube.
  • General anesthetic drugs are used in millions of children every year to ensure their health, safety and comfort during surgery and other procedures.
Additional Information for Parents and Caregivers
  • Anesthetic and sedation drugs are necessary for infants and children who require surgery or other painful or stressful procedures. Additionally, untreated pain can be harmful to children and their developing nervous systems.
  • Research suggests that repeated or prolonged use of general anesthetic or sedative drugs may be associated with negative effects on the developing brain.
  • These effects are subtle and may include learning, memory, or behavior problems.
  • The FDA has issued a warning that this may affect children younger than 3 years who are undergoing anesthesia for more than three hours, or are exposed to repeated anesthetics.
  • Recent studies in children suggest that a single, short duration exposure to general anesthetic and sedation drugs under age 3 years is unlikely to have negative effects on behavior or learning.
  • No specific anesthetic or sedative medications have been shown to be safer than any other.
  • Parents and caregivers should ask for information about the planned surgery or procedure, including duration of anesthesia and need for any repeated procedures.
  • Parents should discuss with their anesthesiologist and surgeon the potential adverse effects of anesthesia and brain development and appropriate timing of procedures that could be delayed without jeopardizing their child’s health.
  • Examples of life-threatening conditions in newborns and other children younger than 3 years that require surgery or other procedures that should not be delayed include, but are not limited to:
    • Congenital heart defects
    • Esophageal atresia, a disorder in which the esophagus does not develop properly
    • Intestinal blockage or twisting of the intestines
    • Gastroschisis and omphalocele, which are birth defects of the abdominal wall
    • Diaphragmatic hernia, which is a birth defect in which there is an abnormal opening in the diaphragm
    • Congenital lung lesions
    • Pyloric stenosis, which is a narrowing of the opening from the stomach into the small intestine
    • Craniofacial reconstruction
    • Complex urological reconstruction
  • Examples of other common procedures for non-life-threatening conditions in children younger than 3 years that are necessary and should not be delayed are cleft lip or palate repair and surgery to repair undescended testicles in boys.
  • If you have further questions about your child’s care, talk to your anesthesiologist and surgeon.
  • Other useful resources:
    • SmartTots website: www.smarttots.org
    • Society for Pediatric Anesthesia website: pedsanesthesia.org
    • U.S. FDA Website: www.fda.gov
Click here for a PDF version

Filed Under: News and Resources

SPA Response to the FDA Med Watch December 16, 2016

On Wednesday, December 14, the United States Food and Drug Administration (FDA) released a Drug Safety Communication warning that; “repeated or lengthy use of general anesthetic or sedation drugs during surgeries or procedures in children younger than three years of age or in pregnant women during the final trimester may affect development of children’s brains”. The FDA defined lengthy as greater than three hours of exposure.

While there is abundant animal data concerning suspected toxicities in prolonged and multiple anesthetics, the accumulated human data suggest that one brief anesthetic is not associated with cognitive or behavioral abnormalities in children. Most but not all studies in children do however suggest an association between repeated and or prolonged exposure and subsequent difficulties with learning or behavior. It is not yet known whether the anesthetic drug or some other factor is responsible for these findings. Rigorous research to further characterize any possible associations is ongoing.

The data reviewed by the FDA in making the decision to issue this labelling change have accumulated over more than a decade and has been discussed at three separate FDA advisory committee meetings since 2007. This warning appears to have been issued to raise awareness among practitioners and the public to ensure the information needed to make informed judgments about the risks and benefits of anesthesia and sedation in young children and pregnant women is widely available.

The potential risk of negative cognitive or behavioral effects of anesthetic agents remains uncertain and must be placed in the context of the known risks and benefits of both the anesthetic and the related surgical or diagnostic procedure for which the anesthetic is required. Clinicians and parents are cautioned against the possible risk of delaying needed surgical or diagnostic procedures. Until additional information is available from ongoing studies, parents and providers should carefully weigh the risk and benefit of each contemplated procedure before proceeding.

Click to read the complete FDA statement

Additional information may also be found at the following web site: smarttots.org. SmartTots is a public private partnership between the FDA and the International Anesthesia Research Society. The above statement represents a consensus of each of the following organizations all of which share a commitment to health and safety of children and pregnant women.

Filed Under: News and Resources

Enrollment is Open for ACS Children’s Surgery Verification Quality Improvement Program

The new program’s standards to improve surgical care for children are the nation’s first and only multispecialty standards of their kind

CHICAGO (January 31, 2017): Hospitals interested in enrolling in the American College of Surgeons (ACS) Children’s Surgery Verification (CSV) Quality Improvement Program may now file a Pre-Application online for participation in the program. ACS, in collaboration with the Task Force for Children’s Surgical Care, developed standards to improve surgical care for children who are surgical patients, which led to the development of this program. The standards are supported by the American Pediatric Surgical Association, the Society of Pediatric Anesthesia, and the American Academy of Pediatrics.

www.facs.org

Filed Under: News and Resources

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Upcoming Meeting Information

SPA 39th Annual Meeting
October 10, 2025
Grand Hyatt San Antonio River Walk
San Antonio, TX

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