Question of the Week #14

A 2-day old term neonate is undergoing an exploratory laparotomy for duodenal atresia. Anesthetic induction is planned with propofol, fentanyl, and rocuronium. Which of the following pharmacologic considerations is MOST accurate when using rocuronium in this neonate, as compared to an adult?

A. A higher dose is required secondary to immature neuromuscular transmission.

B. The volume of distribution is smaller secondary to decreased total body water.

C. The onset of action is faster secondary to a relative increase in cardiac output.

D. More frequent dosing is required secondary to increased metabolism and clearance.

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Question of the Week #14

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