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Remembering the Classics: MH
Henry Rosenberg MD

Original article
Pawar S,  Rosenberg H,  Adamson R,  LaRosa J, Chamberlain R. Dantrolene in the Treatment of Refractory Hyperthermic Conditions in Critical Care: A Multicenter Retrospective Study Open Journal of Anesthesiology Vol.05 No.04(2015) DOI: 10.4236/ojanes.2015.54013

A positive response to dantrolene in the critical care unit is not necessarily indicative that the causative diagnosis was malignant hyperthermia. It is useful in the treatment

CO2 Monitoring Review
Myron Yaster, MD

Original article
Susan Humphreys, Andreas Schibler, Britta S von Ungern-Sternberg. Carbon dioxide monitoring in children-A narrative review of physiology, value, and pitfalls in clinical practice. Paediatr Anaesth. 2021 Aug;31(8):839-845. PMID: 3400890

This review paper is a must read for all trainees and for those who teach them (and perhaps for all of the rest of us too).

Methadone Redux
Myron Yaster, MD

Original article
Sadhasivam S, Aruldhas BW, Packiasabapathy S, Overholser BR, Zhang P, Zang Y, Renschler JS, Fitzgerald RE, Quinney SK. A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects. Anesth Analg. 2021 Aug 1;133(2):327-337. PMID: 33481403

Editorial
Elizabeth De Souza , T Anthony Anderson. Pediatric Perioperative Methadone Dosing Trial: An Illustration of the Challenges in Conducting High-Quality Pediatric Anesthesia Research. Anesth Analg. 2021 Aug 1;133(2):324-326. PMID: 34257193

Smaller scheduled doses of methadone, along with acetaminophen, nsaids, and naloxegol produced sustained analgesia, opioid sparing, and no respiratory depression or QT prolongation.